15863-33-9Relevant academic research and scientific papers
Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions
Yuan, Wen-Kui,Liu, Yan Fang,Lan, Zhenggang,Wen, Li-Rong,Li, Ming
supporting information, p. 7158 - 7162 (2018/11/25)
An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.
Cerium ammonium nitrate-catalyzed aerobic oxidative coupling of dithiocarbamates: Facile synthesis of thioureas and bis(aminothiocarbonyl)disulfides
Li, Tian-Tian,Song, Xiang-Hai,Wang, Mei-Shuang,Ma, Ning
, p. 40054 - 40060 (2014/12/10)
Diverse disubstituted and trisubstituted thioureas were synthesized by the condensation of dithiocarbamate TEA (or DABCO) salts and amines using cerium ammonium nitrate (CAN) as a catalyst in high yields at room temperature. It is a one-pot method and it is unnecessary to isolate isothiocyanates. This reaction probably took place through nucleophilic addition of amines to isothiocyanates, which were generated by oxidative coupling of dithiocarbamates and the following decomposition of bis(aminothiocarbonyl)disulfides. When secondary amines and CS2served as the reactants, bis(aminothiocarbonyl)disulfides were obtained via tandem nucleophilic addition/oxidative coupling reactions in moderate to excellent yields. In all the coupling reactions, the oxidant was air and CAN possibly acted as an SET catalyst.
The HgCl2-promoted guanylation reaction: The scope and limitations
Levallet, Catherine,Lerpiniere, Joanne,Ko, Soo Y.
, p. 5291 - 5304 (2007/10/03)
The HgCl2-promoted guanylation reaction was studied with various substituted thiourea starting materials and the scope and limitations are presented. The process was found to be effective with thioureas containing at least one N-conjugated subs
Guanidine derivatives
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, (2008/06/13)
Guanidine derivatives of the formula: STR1 in which R1 is a cyclohexyl, adamantyl, bicycloheptanyl, bicycloheptenyl, tricycloheptanyl or tetracyclononanyl radical and R2 is a phenyl or pyridyl radical optionally substituted by 1 or 2 halogen atoms, or alkyl, cyanoalkyl, alkoxycarbonyl or amino radicals, and the pharmaceutically-acceptable acid-addition salts thereof, active against rhinoviruses, are disclosed, along with processes for their manufacture, compositions containing them, a method of combatting rhinoviral infections and a method of selectively killing rhinoviruses in a mixed virus population.
