158664-76-7Relevant academic research and scientific papers
Indenone synthesis. Improved synthetic protocol and effect of substitution on the intramolecular Friedel-Crafts acylation
Galatsis, Paul,Manwell, Jeffrey J.,Blackwell, James M.
, p. 1656 - 1659 (2007/10/02)
An improved protocol for the construction of substituted indenones is presented. Also the effect of substitution on the intramolecular Friedel-Crafts acylation was noted. Specifically, if there is no substitution at the 2-position of the indenone poor yields of cyclized material were obtained, if at all, while the substitution of a methyl or ethyl group greatly improved the yield of cyclized material. Placement of a large group (e. g., benzyl) resulted in a diminuation of the improved yield. The new synthetic procedure could, in principle, allow for the construction of 2,3-disubstituted indenones. One example of this reaction mode was presented.
