1586765-15-2

Upstream product

• 210159-05-0 5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxylic acid 
• 88958-20-7 C₁₁H₁₀ClN₃O 
• 942-26-7 5-chlorotryptamine hydrochloride 

Downstream Products

• 1586765-21-0 1-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-6-chloro-4,9-dihydro-3H-β-carboline 
• 1586765-09-4 1-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-6-chloro-9H-β-carboline 

Relevant academic research and scientific papers

Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl) ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3- triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.