158703-25-4Relevant academic research and scientific papers
Stereoselective 1,4-addition of Grignard reagents to chiral γ-alkoxy-α,β-unsaturated ketones
Raczko, Jerzy
, p. 3821 - 3828 (2007/10/03)
Copper-catalyzed conjugate addition reactions of Grignard reagents to γ-alkoxy-α,β-unsaturated ketones, derived from mandelic acid, have been studied. Diastereoselectivity is strongly dependent on the nature of the γ-alkoxy protection group. Bulky silyl protection gives poor stereoselectivities, whereas the ketone bearing benzyloxymethylene (BOM) protection reacts with excellent yields and stereoselectivities.
