15871-57-5 Usage
Uses
Used in Chemical Industry:
2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid is used as a stable free radical spin label for its ability to provide information on molecular motion, structure, and dynamics in various chemical systems. Its unique properties make it a valuable tool for studying the behavior of molecules in different environments.
Used in Pharmaceutical Industry:
As an EPR probe, 2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid is used in the pharmaceutical industry to study the structure and dynamics of biological macromolecules, such as proteins and nucleic acids. This information can be crucial for understanding the mechanisms of drug action and designing new therapeutic agents.
Used in Material Science:
In the field of material science, 2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid is used as a spin label to investigate the properties of various materials, such as polymers and nanocomposites. Its ability to provide insights into molecular motion and interactions can help in the development of new materials with improved performance and functionality.
Used in Research and Development:
2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid is used as a research tool in various scientific disciplines, including chemistry, biochemistry, and physics. Its role as an EPR probe allows researchers to study the behavior of molecules and materials at a fundamental level, contributing to the advancement of scientific knowledge and the development of new technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 15871-57-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,8,7 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15871-57:
(7*1)+(6*5)+(5*8)+(4*7)+(3*1)+(2*5)+(1*7)=125
125 % 10 = 5
So 15871-57-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2O3/c1-8(2)5-10(11,7(13)14)6-9(3,4)12(8)15/h15H,5-6,11H2,1-4H3,(H,13,14)
15871-57-5Relevant academic research and scientific papers
α-helical versus 310-helical conformation of alanine-based peptides in aqueous solution: An electron spin resonance investigation
Smythe, Mark L.,Nakaie, Clovis R.,Marshall, Garland R.
, p. 10555 - 10562 (2007/10/03)
Due to the difficulties in experimentally differentiating between the α- and 310-helical conformations in solution, isolated helical peptides have been assumed to be in the α-helical conformation. However, recent electron spin resonance (ESR) studies have suggested that such peptides, in particular short alanine-based peptides, are 310-helical (Miick, S. M.; et al. Nature 1992, 359, 653-5). This result prompted us to further investigate the helical conformations of alanine-based peptides in solution using electron spin resonance spectroscopy. Unlike previous investigations with a flexible link connecting the spin-label to the peptide backbone, we used a conformationally constrained spin-label (4-amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl, Toac) that is rigidly attached to the peptide backbone. From a combination of molecular modeling and ESR spectroscopy investigations, it was concluded that these alanine-based peptides exist primarily in the α-helical conformation, and not the 310-form as previously suggested for an analogous set of peptides in aqueous environments. This discrepancy is thought to be due to the differences in flexibility of the spin-labels employed. The conformationally constrained spin-label Toac used in this study should accurately reflect the backbone conformation. Free energy surfaces, or potentials of mean force, for the conformational transition of the spin-label used in previous studies (Miick S. M.; et al. Nature 1992, 359, 653-5) suggest that this spin-label is too flexible to accurately distinguish between the α- and 310-helical conformations.
