15871-63-3Relevant academic research and scientific papers
4-aminopyrazolo [3, 4-d] pyrimidine derivative and application thereof
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Paragraph 0077-0079; 0083-0085, (2021/08/19)
The invention discloses a 4-aminopyrazolo [3, 4-d] pyrimidine derivative and application thereof, the structure of the derivative is as shown in formula I, A is an aromatic ring group or an aromatic heterocyclic group; L is fat alkane; Cyclic is of an N-containing heterocyclic structure; Q is carbonyl or sulfonyl; R is alkane, aryl or heteroaryl. A novel 4-aminopyrazolo [3, 4-d] pyrimidine derivative is synthesized and screened, the activity of an ALK5 receptor can be inhibited in a dose-dependent mode, and the derivative or a solvate and a medicinal salt of the derivative can be applied to preparation of drugs for treating and/or preventing cancers.
KINASE ANTAGONISTS AND METHODS FOR MAKING AND USING THEM
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, (2020/02/19)
Disclosed herein are small molecule compounds that are SGK1 antagonists, formulations and pharmaceutical compositions comprising the compounds, and methods of making and using them, for treating, ameliorating, preventing, reversing or slowing the progression of: a cancer, a tumor, a metastasis or a dysplastic or a dysfunctional cell condition responsive to inhibition of a kinase enzyme of the AGC group of kinases including SGK1, by administration of an AGC kinase inhibitor or antagonist.
IDO inhibitors
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Page/Page column 215-216, (2015/11/27)
Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for mod
