78056-59-4

Upstream product

• 59184-90-6 ethyl (piperidin-4-yl)acetate 
• 108-88-3 toluene 
• 75-36-5 acetyl chloride 

Downstream Products

• 15871-63-3 1-acetyl-4-(2-hydroxyethyl)piperidine 
• 639468-66-9 4-[2-(4-fluorophenyl)-2-hydroxyethyl]piperidine-1-carboxylic acid tert-butyl ester 
• 639468-64-7 4-(2-hydroxy-2-phenylethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 137996-01-1 4-<2-(4-fluorophenyl)-2-oxoethyl>piperidine 
• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 78056-63-0 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone 
• 6719-96-6 1-phenyl-2-(piperidin-4-yl)ethanone 
• 78056-60-7 (1-acetylpiperidin-4-yl)acetic acid 

Relevant academic research and scientific papers

KINASE ANTAGONISTS AND METHODS FOR MAKING AND USING THEM

Disclosed herein are small molecule compounds that are SGK1 antagonists, formulations and pharmaceutical compositions comprising the compounds, and methods of making and using them, for treating, ameliorating, preventing, reversing or slowing the progression of: a cancer, a tumor, a metastasis or a dysplastic or a dysfunctional cell condition responsive to inhibition of a kinase enzyme of the AGC group of kinases including SGK1, by administration of an AGC kinase inhibitor or antagonist.

1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives

Novel 1,3-dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives which compounds are potent serotonin-antagonists and central nervous system depressants, having utility as antiemetic, neuroleptic and anti-congestive agents.