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N2-(4-n-Butylphenyl)-2'deoxy-3,5'-cycloguanosine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

158729-54-5

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158729-54-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 158729-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,7,2 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 158729-54:
(8*1)+(7*5)+(6*8)+(5*7)+(4*2)+(3*9)+(2*5)+(1*4)=175
175 % 10 = 5
So 158729-54-5 is a valid CAS Registry Number.

158729-54-5Downstream Products

158729-54-5Relevant academic research and scientific papers

Synthesis of the P1, P2-methylene analog of N2-(p-n-butylphenyl)-2'- deoxyguanosine 5'-triphosphate: A non-substrate inhibitor of DNA polymerases

Yanachkov,Wright

, p. 339 - 350 (2007/10/02)

N2-(p-n-Butylphenyl)-2'-deoxyguanosine 5'-(P1, P2-methylene)- triphosphate (BuPdGMPCH2PP) has been synthesized. Displacement of the mesyloxy group of 5'-MesBuPdG by methanediphosphonate gave 30% of BuPdGMPCH2P, but 68% of 3,5'-cycloBuPdG. Reaction of the nucleoside BuPdG with methanediphosphonate and DCC gave 62% of BuPdGMPCH2PPCH2P, which was hydrolyzed to BuPdGMPCH2P in 77% yield. The title compound was obtained by reacting the imidazolide of BuPdGMPCH2P with orthophosphate. BuPdGMPCH2PP inhibited calf thymus DNA polymerase α with K(i) = 9.5 nM, a potency only fivefold weaker than that of BuPdGTP itself.

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