158749-48-5Relevant academic research and scientific papers
Synthesis and properties of new luminescent 10-carboxymethylacridinium derivatives
Sato, Naofumi
, p. 8519 - 8522 (2007/10/03)
A novel method was developed to synthesize acridinium esters having a binding functional group at N-10. An acridine ester having steric hindrance is synthesized quickly, with excellent yields, using dimethylaminopyridine as a catalyst. Alkylation of the N-10 on the acridine ring proceeds using the trifluoromethanesulfonic acid ester under mild conditions. Deprotection of the benzyl ester using acid thus enables simple, high-yield synthesis for acridinium compounds with a binding functional group at N-10.
Acridinium compounds and conjugates thereof
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, (2008/06/13)
Acridinium compounds represented by the general formula (I) where A is an intervening group which does not have activity for binding with a specific binding substance, Z is a labelling active group which has activity for binding with a specific binding substance, R1 is a halogen atom, an alkyl group or an aryl group; R2, R3, R4 and R5 are each a hydrogen atom, an alkyl group, an aryl group, an alkoxy group, a nitro group, a halogen atom or a carbonyl group, and Y is a counter ion. The acridinium compounds may form conjugates with specific binding substances. The acridinium compounds have high emission efficiency and stability and, hence, are useful as chemiluminescence labelling agents.
