15875-47-5Relevant academic research and scientific papers
An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates
Khaligh, Nader Ghaffari,Mihankhah, Taraneh,Johan, Mohd Rafie
, (2019/03/17)
This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process
Nickel nanoparticles catalyzed chemoselective Knoevenagel condensation of Meldrum's acid and tandem enol lactonizations via cascade cyclization sequence
Khurana, Jitender M.,Vij, Kanika
experimental part, p. 3666 - 3669 (2011/07/29)
A novel protocol has been reported wherein, polyethylene glycol (PEG) stabilized nickel nanoparticles have been used as catalyst for chemoselective Knoevenagel condensation of aromatic aldehydes and Meldrum's acid to give 5-arylidene Meldrum's acid which underwent tandem enol lactonization by Michael addition/cyclization sequence with active methylene compounds in the presence of Ni nanoparticles to give corresponding enol lactone derivatives.
A novel light induced Knoevenagel condensation of Meldrum's acid with aromatic aldehydes in aqueous ethanol
Ghosh, Somnath,Das, Jhantu,Chattopadhyay, Subhagata
experimental part, p. 2869 - 2872 (2011/06/21)
A highly efficient environment-friendly photochemical methodology has been developed for the condensation of Meldrum's acid with aromatic aldehydes in water-ethanol solution sans any catalyst, support or promoter.
Natural α-amino acid l-lysine-catalyzed knoevenagel condensations of α,β-unsaturated aldehydes and 1,3-dicarbonyl compounds
He, Yan-Hong,Hu, Ying,Guan, Zhi
experimental part, p. 1617 - 1628 (2011/06/21)
Knoevenagel condensations of α,β-unsaturated aldehydes and 1,3-dicarbonyl compounds were catalyzed by primary natural amino acid L-lysine. The reactions were carried out at room temperature in dimethylsulfoxide. It provides a facile entry to a wide variety of α,β,γ,δ- unsaturated dicarbonyl compounds. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents
Sandhu, Harmeet S.,Sapra, Sameer,Gupta, Mukesh,Nepali, Kunal,Gautam, Raju,Yadav, Sunil,Kumar, Raj,Jachak, Sanjay M.,Chugh, Manoj,Gupta, Manish K.,Suri, Om P.,Dhar
experimental part, p. 5626 - 5633 (2010/09/11)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (), donor number (DN
Knoevenagel condensation of aldehydes with Meldrum's acid in ionic liquids
Tahmassebi, Daryoush,Wilson, Levi J. A.,Kieser, Jerod M.
experimental part, p. 2605 - 2613 (2009/12/04)
The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF4 at room temperature in the presence of catalytic amounts of piperidine.
Ionic liquid-mediated knoevenagel condensation of Meldrum's acid and aldehydes
Darvatkar, Nitin B.,Deorukhkar, Amol R.,Bhilare, Sachin V.,Salunkhe, Manikrao M.
, p. 3043 - 3051 (2007/10/03)
A simple, efficient, and green protocol for Knoevenagel condensation of Meldrum's acid and aldehydes in ionic liquid at room temperature without any catalyst is described. The reaction has been performed in different ionic liquids. The enhancement in the
Organic reactions in ionic liquids: Ionic liquid ethylammonium nitrate-promoted knoevenagel condensation of meldrum's acid with aromatic aldehydes
Hu, Yi,Wei, Ping,Huang, He,Le, Zhang-Gao,Chen, Zhen-Chu
, p. 2955 - 2960 (2007/10/03)
The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in a reusable ionic liquid, ethylammonium nitrate, at room temperature in the absence of any catalyst with high yields. Copyright Taylor & Francis, Inc.
Reaction of Stabilized Bismuthonium Ylides with Aldehydes. A Novel Reaction Mode of the Heaviest Group V Element Ylide
Ogawa, Takuji,Murafuji, Toshihiro,Suzuki, Hitomi
, p. 849 - 852 (2007/10/02)
Stabilized bismuthonium ylides, triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide and triphenylbismuthonio-4,4-dimethyl-2,6-dioxo-3,5-dioxan-1-ide, react with aldehydes to afford three types of products; tetraacylcyclopropanes, dihydrofurans, and α,β-unsaturated carbonyl compounds, the relative importance of these depending greatly on the ylides, aldehydes, and reaction conditions employed.
