15875-59-9

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 6630-33-7 ortho-bromobenzaldehyde 
• 117560-06-2 3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide 

Downstream Products

• 103966-51-4 2-[1-(2-Bromo-phenyl)-3-oxo-3-phenyl-propylidene]-indan-1,3-dione 
• 1612772-28-7 (E)-2-benzylidene-5-(2-bromophenyl)spiro[cyclopentane-1,2'-indene]-1',3,3'-trione 

Relevant academic research and scientific papers

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy

Styryl and functionalized aryl derivatives of lawsone through metal-free cross-coupling of its BF3-activated phenyliodonium ylide with cinnamaldehydes and arylaldehydes

Phenyliodonium ylide of lawsone activated with BF3?Et2O reacts with cinnamaldehydes to afford 2-hydroxy-3-styryl-1,4-naphthoquinones in good to excellent yields and relatively high level of stereospecificity through deformylation of the aldehydes. The product yield is diminished with a methoxy substituted cinnamaldehyde and becomes zero with a dimethoxy substituted substrate giving rise to another product, 2-hydroxy-3-aryl-1,4-naphthoquinone. The reaction of the same ylide with salicylic aldehydes forms 2-hydroxy-3-(2-hydroxyaryl)-1,4-naphthoquinones and/or benzo[d]naphtha[2,1-b]furano-5,6-diones, depending on the reaction conditions applied. Plausible reaction mechanisms explaining the formation of these products are proposed. The products showed potent antioxidant activity and inhibited lipoxygenase.

Phosphine-catalyzed [4 + 2] annulation of γ-substituent allenoates: Facile access to functionalized spirocyclic skeletons

The first phosphine-catalyzed [4 + 2] annulation of γ-substituted allenoates with 2-arylidene-1H-indene-1,3(2H)-diones is disclosed. In the reaction, the γ-substituted allenoate serves as a new type of 1,4-dipolar synthon; this broadens the application of

Reaction of selenonium monoketoylides with 2-arylideneindanediones

The reaction of selenonium monoketoylide with 2-arylidene-1,3-indanediones was investigated.Dihydrofurans with various structures or 2-(α-phenacylarylidene)-1,3-indanediones are formed, depending on the nature of the arylidene group.