117560-06-2Relevant articles and documents
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3)
Li, Chungen,Chen, Caili,An, Qi,Yang, Tao,Sang, Zitai,Yang, Yang,Ju, Yuan,Tong, Aiping,Luo, Youfu
, p. 543 - 554 (2019)
The transcription factor STAT3 is an attractive target for a variety of cancers therapy. Napabucasin, applied in phase III clinical trials for the treatment of a variety of cancers, was regarded as one of the most promising anticancer drug by targeting ST
Synthetic method of napabucasin homolog
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Paragraph 0032-0036, (2020/03/02)
The invention discloses a synthetic method of a napabucasin homolog, wherein the synthetic method comprises the steps: weighing 60 g of 2-hydroxy-1,4-naphthoquinone, measuring to take 1000 mL of dichloromethane, adding the raw materials into a single-mout
METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE
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Paragraph 0369-0371, (2019/03/08)
Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of
Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from Tabebuia plants
Inagaki, Ryuta,Ninomiya, Masayuki,Tanaka, Kaori,Watanabe, Kunitomo,Koketsu, Mamoru
, p. 670 - 673 (2013/07/11)
Furonaphthoquinones are promising skeletons for anticancer drug molecules. In particular, methoxylated furonaphthoquinones are characteristic constituents of Tabebuia plants. In this research, we synthesized the furonaphthoquinones by effective one-pot ca
1,4-naphthoquinone cations as antiplasmodial agents: Hydroxy-, acyloxy-, and alkoxy-substituted analogues
Lu, Xiao,Altharawi, Ali,Gut, Jiri,Rosenthal, Philip J.,Long, Timothy E.
supporting information, p. 1029 - 1033 (2013/02/22)
Cations of hydroxy-substituted 1,4-naphthoquinones were synthesized and evaluated as antiplasmodial agents against Plasmodium falciparum. The atovaquone analogues were found to be inactive as antagonists of parasite growth, which was attributed to ionization of the acidic hydroxyl moiety. Upon modification to an alkoxy substituent, the antiplasmodial activity was restored in the sub-100 nM range. Optimal inhibitors were found to possess IC50 values of 17.4-49.5 nM against heteroresistant P. falciparum W2.
A convenient approach to fused indeno-1,4-diazepinones through hypervalent iodine chemistry
Malamidou-Xenikaki, Elizabeth,Spyroudis, Spyros,Tsanakopoulou, Maria,Hadjipavlou-Litina, Dimitra
body text, p. 7315 - 7321 (2010/01/16)
(Chemical Equation Presented) Indenocarboxamides, resulting from the sequential addition of two arylamine equivalents to indanedione ketene dimer, are oxidized by [bis(trifluoroacetoxy)iodobenzene] to fused indeno-1,4- diazepinones in yields depending on the substituents on both aromatic rings. A plausible reaction pathway explaining the formation of the title compounds, as well as the formation of the two other minor products of the reaction, through a common intermediate, is suggested. 2009 American Chemical Society.
Synthesis of furanonaphthoquinones with hydroxyamino side chains
Wu, Chongming,Johnson, Randall K.,Mattern, Michael R.,Wong, Jackson C.,Kingston, David G. I.
, p. 963 - 968 (2007/10/03)
Several furanonaphthoquinones have shown useful activity in a yeast assay for DNA-damaging agents and cytotoxicity in mammalian cell culture assays. These results, together with the planar aromatic character of the furanonaphthoquinones, suggested that th
Derivatives of 1,4-Naphthoquinone via 3-(Phenyliodonio)-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide
Hatzigrigoriou, Evangelia,Spyroudis, Spyros,Varvoglis, Anastasios
, p. 167 - 170 (2007/10/02)
The title compound 3 reacts with various electrophiles such as hydrogen halides, benzoyl chloride, iodomethane, and bromine to afford 3-halo derivatives of 2-hydroxy-1,4-naphthoquinone. 3 reacts also with dimethyl sulfide to give a trans-ylidation product; photochemically, furan derivatives are formed with 2-methyl-2-butene, styrene, and phenylacetylene.Carbon disulfide affords the 2-thioxo-1,3-oxathiole derivative 15.