158751-36-1

Upstream product

• 157117-37-8 (E,E,7S)-methyl-8-<(2R,6S)-6-<(2S,3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-2-methoxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-... 
• 158751-34-9 (E,E,7S)-methyl-8-<(2R,6S)-6-<(2S,3R,4S,6R,7R,8R,9S,10S,11S)-2-methoxy-3,7,9,11-tetramethyl-8,10-dihydroxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-tridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-7-tert-... 
• 158751-35-0 (E,E,7S)-8-<(2R,6S)-6-<(2S,3R,4S,6R,7R,8R,9S,10S,11S)-2-methoxy-3,7,9,11-tetramethyl-8,10-dihydroxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-tridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-7-tert-butyldi... 

Relevant academic research and scientific papers

The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A

Swinholide A and isoswinholide A were synthesized in 7 steps from the fully protected seco acid 4. Key steps include: (i) bimolecular acylation, 7 + 10 → 12, (ii) selective hydrolysis of the methyl ester, 16 → 17, and (iii) regioselective macrolactonisati