158751-35-0Relevant academic research and scientific papers
The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A
Paterson, Ian,Yeung, Kap-Sun,Ward, Richard A.,Smith, Julian D.,Cuimming, John G.,Lamboley, Serge
, p. 9467 - 9486 (1995)
Swinholide A and isoswinholide A were synthesized in 7 steps from the fully protected seco acid 4. Key steps include: (i) bimolecular acylation, 7 + 10 → 12, (ii) selective hydrolysis of the methyl ester, 16 → 17, and (iii) regioselective macrolactonisati
