158754-46-2

Basic information

• Product Name: 8-Oxo-Benzylguanine
• Synonyms: 8-Oxo-Benzylguanine
• CAS NO: 158754-46-2
• Molecular Formula: C12H11N5O2
• Molecular Weight: 257.24804
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents
• Mol File: 158754-46-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 8-Oxo-Benzylguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Oxo-Benzylguanine(158754-46-2)
• EPA Substance Registry System: 8-Oxo-Benzylguanine(158754-46-2)

Safety Data

• Hazardous Substances Data: 158754-46-2(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

8-Oxo-Benzylguanine is a derivative of O-Benzylguanine, an reversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. O-Benzylguanine is known to assists in the protection against carcinogenic and therapeutic alkylating agents.

Relevant articles and documents

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors

Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic pathological diseases due to the chronic production of hypochlorous acid, as well as other reactive radical species. A high throughput screen and triaging protocol was developed to identify a reversible inhibitor of myeloperoxidase toward the potential treatment of chronic diseases such as atherosclerosis. The identification and characterization of a reversible myeloperoxidase inhibitor, 7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine is described.