158761-03-6Relevant articles and documents
Total synthesis of (-)-mniopetal F, a novel inhibitor of RNA-directed DNA-polymerases
Suzuki, Yoshikazu,Ohara, Aiko,Sugaya, Kenji,Takao, Ken-Ichi,Tadano, Kin-Ichi
, p. 7291 - 7301 (2007/10/03)
We have achieved a total synthesis of (-)-mniopetal F, a drimane-type sesquiterpenoid which inhibits the reverse transcriptase activity of the human immunodeficiency virus (HIV)-1. The key step in our enantiospecific synthesis is a stereoselective intramolecular Diels-Alder reaction, in which the π-facial selectivity is controlled by the stereoelectronic effect of a trialkylsilyloxy substituent existing adjacent to the dienophile part.