1587688-67-2Relevant academic research and scientific papers
Metal-free trifluoroethylation of activated alkenes: Rapid access to construct fluorinated 3,3-disubstituted 2-oxindoles
Mai, Wen-Peng,Sun, Bin,Qian, Guan-Sheng,Yuan, Jin-Wei,Mao, Pu,Yang, Liang-Ru,Xiao, Yong-Mei
, p. 8416 - 8423 (2015)
A novel and mild fluorination/cyclization reaction of activated alkenes under metal-free conditions has been developed. Fluorinated radicals were produced from halogenated hydrocarbons by simple rongalit, meanwhile, no metal and extra base are needed. Thi
Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes
Wang, Jian-Yong,Su, Yi-Ming,Yin, Feng,Bao, Yan,Zhang, Xin,Xu, Yue-Ming,Wang, Xi-Sheng
supporting information, p. 4108 - 4111 (2014/04/03)
A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new method for construction of a variety of difluoromethylated oxindoles. Mechanistic investigations indicate that a difluoromethyl radical, which was triggered by Pd(0), initiated the cascade sequence through an addition to the alkene. This journal is the Partner Organisations 2014.
Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles
Wang, Jian-Yong,Zhang, Xin,Bao, Yan,Xu, Yue-Ming,Cheng, Xiu-Fen,Wang, Xi-Sheng
supporting information, p. 5582 - 5585 (2014/07/22)
An iron-catalyzed aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed, which is a rare example where a cosolvent is used to improve the reaction yield along with Fenton's reagent and thus provides an economic and green method for the synthesis of a variety of difluoromethylated oxindoles. Preliminary mechanistic investigations indicate a radical addition path. the Partner Organisations 2014.
