802919-90-0

Usage

Uses

Used in Organic Synthesis:
DifluoroiodoMethyl phenyl sulfone is used as a reagent for the preparation of diaryliodonium salts, which are important intermediates in various chemical reactions.
Used in Fluorination and Iodination Reactions:
DifluoroiodoMethyl phenyl sulfone is utilized in fluorination and iodination reactions due to its unique properties, making it a valuable tool in the development of new synthetic methodologies.
Used in Pharmaceutical and Agrochemical Production:
DifluoroiodoMethyl phenyl sulfone is also used in the production of pharmaceuticals and agrochemicals, where its reactivity and ability to transfer atoms play a crucial role in creating effective and novel products.

Upstream product

• 536975-50-5 [difluoro(phenylsulfonyl)methyl](trimethyl)silane 
• 80351-58-2 [(bromodifluoromethyl)sulfonyl]benzene 
• 465512-53-2 benzenesulfinyl-difluoro-acetic acid 
• 935426-17-8 (difluoro-iodo-methanesulfinyl)-benzene 
• 1535-65-5 difluoromethyl phenyl sulfone 

Downstream Products

• 946485-28-5 C₁₅H₁₉F₂IO₄S 
• 946485-24-1 C₁₃H₁₇F₂IO₂S 
• 946485-25-2 C₁₉H₂₉F₂IO₂S 
• 946485-26-3 C₁₂H₁₇F₂IO₂SSi 
• 946485-27-4 C₁₃H₁₅F₂IO₃S 
• 1587688-68-3 C₂₄H₂₁F₂NO₃S 
• 1587688-77-4 C₁₉H₁₉F₂NO₄S 

Relevant academic research and scientific papers

A novel method for the synthesis of aryl trihalomethyl sulfones and their derivatization: The search for new sulfone fungicides

A novel method for the preparation of bioactive aryl trihalomethyl sulfones is reported. An iodination reaction with iodine bromide is applied for the synthesis of difluoroiodomethyl aryl sulfones. A series of difluoroiodomethylsulfonyl group bearing derivatives is afforded, including nitroanilines and benzimidazoles. Biological studies show high fungicidal activity for a number of the synthesized sulfones.

Copper-mediated fluoroalkylation reactions with [(phenylsulfonyl)- difluoromethyl]trimethylsilane: Synthesis of PhSO2CF 2-containing allenes and alkynes

Copper-mediated (phenylsulfonyl)difluoromethylation of propargyl chlorides and alkynyl halides with PhSO2CF2TMS reagent was successfully achieved to give PhSO2CF2-containing allenes and alkynes, respectively. It is believed that the in situ formed PhSO 2CF2Cu species is involved in the present (phenylsulfonyl)difluoromethylation reactions. Georg Thieme Verlag Stuttgart · New York.

Aryliododifluoromethylsulfides, sulfoxides and sulfones: The first optically active compounds with polyfluoroalkyliodo groups

Aryliododifluoromethyl sulfoxides, which were transformed in aryliododifluoromethyl sulfides and sulfones, were obtained by the coupling of mercury salts of arylsulfoxydifluoromethylacetic acids with iodine.

NUCLEOPHILIC SUBSTITUTION REACTIONS OF DIFLUOROMETHYL PHENYL SULFONE WITH ALKYL HALIDES LEADING TO THE FACILE SYNTHESIS OF TERMINAL 1,1-DIFLUORO-1-ALKENES AND DIFLUOROMETHYLALKANES

(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (SN2 with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (Benzenesulfonyl) difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF2=” and CF2H” synthons.

Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent

(Chemical Equation Presented) A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluo