1587709-76-9

Upstream product

• 1587709-88-3 2-chloro-6-(methoxymethoxy)quinoline 
• 1587709-89-4 4-(6-(methoxymethoxy)quinolin-2-yl)-N,N-dimethylaniline 
• 1587709-90-7 N,N-dimethyl-4-(6-(oxiran-2-ylmethoxy)quinolin-2-yl)aniline 
• 1374109-24-6 C₁₃H₁₄ClNO₂ 
• 171364-78-6 (4-(N,N-dimethylamino)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 19315-93-6 quinoline-2,6-diol 
• 1246092-42-1 2-(4-(dimethylamino)phenyl)quinolin-6-ol 
• 577967-89-6 6-hydroxy-2-chloroquinoline 

Relevant academic research and scientific papers

TAU IMAGING PROBE

An object of the present invention is to provide a compound represented by formula (I) which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or undetected toxicity.

Enantioselective radiosynthesis of positron emission tomography (PET) tracers containing [18F]fluorohydrins

Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [18F](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. We demonstrate the utility of the method by preparing single enantiomer experimental and clinically validated PET tracers that contain base-sensitive functional groups, epimerizable stereocenters, and nitrogen-rich motifs. Unlike the conventional radiosyntheses of these targets with [18F]KF, labeling with (salen)CoF is possible in the last step and under exceptionally mild conditions. These results constitute a rare example of a nucleophilic radiofluorination using a transition metal fluoride and highlight the potential of such reagents to enhance traditional methods for labeling aliphatic hydrocarbons.