158785-69-4

Basic information

• Product Name: rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate
• Synonyms: rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate
• CAS NO: 158785-69-4
• Molecular Weight: 249.334
• Mol File: 158785-69-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate(158785-69-4)
• EPA Substance Registry System: rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate(158785-69-4)

Safety Data

• Hazardous Substances Data: 158785-69-4(Hazardous Substances Data)

Upstream product

• 89530-19-8 ethyl (4R)-2-phenyl-4,5-dihydrothiazole-4-carboxylate 
• 74-88-4 methyl iodide 
• 1634-04-4 tert-butyl methyl ether 
• 70454-09-0 Ethyl 5,5-dihydro-2-phenyl-2-thiazoline-4-carboxylate 
• 100-47-0 benzonitrile 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 3411-58-3 L-cystein ethyl ester 

Downstream Products

• 62175-38-6 4-methyl-2-phenyl-4,5-dihydro-thiazole-4-carboxylic acid 

Relevant articles and documents

Process for the preparation of substituted thiazolines and their intermediates

Process for the preparation of substituted thiazolines of the formula (I) 1in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) 2with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-a-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).