62175-38-6

Upstream product

• 62096-93-9 2-phenyl-4,5-dihydrothiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 158785-69-4 rac-ethyl 4-methyl-2-phenylthiazoline-4-carboxylate 
• 89530-19-8 ethyl (4R)-2-phenyl-4,5-dihydrothiazole-4-carboxylate 
• 100-47-0 benzonitrile 
• 5333-86-8 ethyl benzimidate hydrochloride 

Downstream Products

• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Process for the preparation of substituted thiazolines and their intermediates

Process for the preparation of substituted thiazolines of the formula (I) 1in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) 2with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-a-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).

Natural Products as Pesticides: Two Examples of Stereoselective Synthesis

The strategy and synthetic efforts leading to efficient stereoselective syntheses of thiangazole, a tris-thiazolinyl-oxazole metabolite isolated from Polyangium spp., and hydantocidin, a spironucleoside metabolite isolated from Streptomyces hygroscopicus, are discussed.