158804-95-6

Basic information

• Product Name: (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester
• Synonyms: (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester
• CAS NO: 158804-95-6
• Molecular Weight: 592.73
• Mol File: 158804-95-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester(158804-95-6)
• EPA Substance Registry System: (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester(158804-95-6)

Safety Data

• Hazardous Substances Data: 158804-95-6(Hazardous Substances Data)

Upstream product

• 158804-93-4 (S)-2-(Benzyloxycarbonyl-methyl-amino)-pentanedioic acid di-tert-butyl ester 
• 5891-45-2 (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester 
• 6753-62-4 N-methyl-L-glutamic acid 
• 42417-69-6 N-(benzyloxycarbonyl)-N-methyl-L-glutamic acid 
• 158804-94-5 (S)-2-Methylamino-pentanedioic acid di-tert-butyl ester 

Downstream Products

• 158805-22-2 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-21-1 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{2-fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-20-0 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-25-5 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158804-96-7 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-24-4 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{2-fluoro-4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-23-3 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 

Relevant articles and documents

Folate-based inhibitors of thymidylate synthase: Synthesis and antitumor activity of γ-linked sterically hindered dipeptide analogues of 2-desamino- 2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of γ-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) was pre