42417-69-6

Upstream product

• 6753-62-4 N-methyl-L-glutamic acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 158805-22-2 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-21-1 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{2-fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-20-0 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-25-5 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158804-96-7 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-24-4 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{2-fluoro-4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158805-23-3 (S)-2-[((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158804-95-6 (S)-2-[((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-methyl-amino]-pentanedioic acid di-tert-butyl ester 
• 158804-93-4 (S)-2-(Benzyloxycarbonyl-methyl-amino)-pentanedioic acid di-tert-butyl ester 

Relevant academic research and scientific papers

Folate-based inhibitors of thymidylate synthase: Synthesis and antitumor activity of γ-linked sterically hindered dipeptide analogues of 2-desamino- 2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of γ-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) was pre

Thymidylate synthase inhibiting quinazolinones

Quinazolines of the formula STR1 wherein R1 is typically methyl, hydrogen or amino; R2 is typically methyl or propargyl; Ar is typically phenylene or 2'-fluorophenylene; R3 is the residue of a dipeptide substituted, typically by methyl, at position (a), (b) or (c), shown in the following partial formula: STR2 R4, R5, R6 and R8 are typically hydrogen, R7 is typically hydrogen or methyl; or a pharmaceutically acceptable salt, ester or amide thereof are of value in the treatment of cancer.