15884-86-3

Usage

Uses

Used in Pharmaceutical Research:
5-(methoxymethyl)-1,3,4-thiadiazol-2-amine (SALTDATA: FREE) is used as a building block in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure and properties make it a promising candidate for the synthesis of compounds with therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine (SALTDATA: FREE) is utilized as a key intermediate for the creation of various organic compounds. Its reactivity and functional groups allow for the formation of diverse chemical entities, expanding the scope of synthetic chemistry.
Used in Drug Development:
5-(methoxymethyl)-1,3,4-thiadiazol-2-amine (SALTDATA: FREE) is employed in drug development as a precursor for the synthesis of pharmaceutically active molecules. Its potential biological activities and ongoing research into its pharmacological properties make it a valuable asset in the discovery and design of new therapeutic agents.
Used in Medicinal Chemistry:
In medicinal chemistry, 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine (SALTDATA: FREE) is used as a structural component in the design of novel compounds with potential medicinal properties. Its incorporation into drug candidates can enhance their efficacy and selectivity, contributing to the advancement of treatments for various diseases.
Used in Biological Research:
5-(methoxymethyl)-1,3,4-thiadiazol-2-amine (SALTDATA: FREE) is also utilized in biological research to study its interactions with biological systems and to explore its potential as a therapeutic agent. This research aims to further understand its biological functions and to identify new applications in medicine.

Upstream product

• 79-19-6 thiosemicarbazide 
• 625-45-6 2-methoxyacetic acid 
• 13779-42-5 chlorophosphoric acid 

Downstream Products

• 1420066-22-3 3-(methoxymethyl)-1-(2-nitrophenyl)-1H-1,2,4-triazol-5-amine 
• 61450-91-7 5-bromo-2-methoxymethyl(1,3,4)thiadiazole 

Relevant academic research and scientific papers

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification

Multifaceted roles of vascular endothelial growth factor (VEGF)-neuropilin-1 (NRP1) interaction have been implicated in cancer, but reports on small-molecule inhibitors of VEGF-NRP1 interaction are scarce. Herein, we describe the identification of 1, a novel nonpeptide small-molecule NRP1 antagonist with moderate activity via structure-based virtual screening. Ensemble docking and molecular dynamics (MD) simulations of 1 were carried out and an interesting binding model was obtained. We found that the “aromatic box” enclosed by Tyr297, Trp301 and Tyr353 of NRP1 is critical for NRP1-1 binding. Further structure modification of 1 based on the binding model derived from MD simulations resulted in the identification of 12a with significantly improved activity.

2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES

The present invention relates to 2-oxo-1-pyrrolidine imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

CERTAIN NITROGEN HETEROCYCLIC ISOTHIOCYANATE ESTERS

Process for preparing thioureas by treating isothiocyanates with ammonia and alkylamines. A specific product is N-methyl-N'-2-((5-methyl-4-imidazolyl)methylthio)ethyl!thiourea, useful as a histamine H. sub.2-antagonist.

PYRIDYL-ALKYLAMINOETHYLENE COMPOUNDS

The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-2-((4-methyl-5-imidazolyl) methylthio)ethylamino!-2-2-((3-chloro-2-pyridyl)methylthio) ethylamino!ethylene.

IMIDAZOLE ALKYLAMINOETHYLENE COMPOUNDS

The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-2-((4-methyl-5-imidazolyl)methylthio)-ethylamino!ethylene.