1588477-15-9

Basic information

• Product Name: ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
• Synonyms: ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
• CAS NO: 1588477-15-9
• Molecular Weight: 570.609
• Mol File: 1588477-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(1588477-15-9)
• EPA Substance Registry System: ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(1588477-15-9)

Safety Data

• Hazardous Substances Data: 1588477-15-9(Hazardous Substances Data)

Upstream product

• 196618-13-0 oseltamivir 
• 204255-06-1 oseltamivir 
• 1132659-99-4 (3R,4S,5R)-4-acetylamino-3-(1-ethyl-propoxy)-5-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester 
• 753-90-2 trifluoroethylamine 
• 1588477-08-0 (3R,4R,5S)-ethyl 4-acetamido-5-(3-((benzyloxy)carbonyl)thioureido)-3-(pentan-3-yloxy)-cyclohex-1-enecarboxylate 
• 1132659-97-2 (3R,4S,5R)-4-[(diethoxyphosphoryl)amino]-3-(1-ethylpropoxy)-5-(methanesulfonyloxy)cyclohex-1-enecarboxylic acid ethyl ester 
• 1151665-75-6 (3R,4S,5R)-3-azido-4,5-bis-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester 
• 1132659-94-9 (3R,4S,5R)-3,4,5-tris-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester 
• 138-59-0 shikimic acid 
• 101769-63-5 (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid ethyl ester 

Downstream Products

• 1588489-27-3 (3R,4R,5S)-4-acetamido-3-(pentan-3-yloxy)-5-((E)-2-(2,2,2-trifluoroethyl)guanidino)cyclohex-1-enecarboxylic acid trifluoroacetate 

Relevant articles and documents

Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors

A series of oseltamivir analogues bearing an N-substituted guanidine unit were prepared and evaluated as inhibitors of neuraminidases from four strains of influenza the two most potent analogues identified contain relatively small N-guanidine substituents (N-methyl and N-hydroxyl) and display enhanced inhibition with IC50 values in the low nanomolar range against neuraminidases from wild-type and oseltamivir-resistant strains. Potential advantages of including the N-hydroxyguanidine moiety in neuraminidase inhibitors are also discussed.