158884-39-0

Basic information

• Product Name: 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate
• Synonyms: 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate
• CAS NO: 158884-39-0
• Molecular Weight: 344.355
• Mol File: 158884-39-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate(158884-39-0)
• EPA Substance Registry System: 2,2,2-trifluoro-1-[2-(methyl)phenyl]ethyl 4-methylbenzenesulfonate(158884-39-0)

Safety Data

• Hazardous Substances Data: 158884-39-0(Hazardous Substances Data)

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 341-39-9 2-methyl-α,α,α-trifluoroacetophenone 
• 438-24-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 158884-43-6 2-(2,2,2-Trifluoroethyl)benzaldehyde tosylhydrazone 
• 158884-12-9 C₉H₆⁽²⁾HF₃N₂ 
• 158884-11-8 <2-(2,2,2-Trifluoroethyl)phenyl>diazomethane 
• 158884-41-4 1-(Bromomethyl)-2-(2,2,2-trifluoroethyl)benzene 
• 158884-42-5 2-(2,2,2-Trifluoroethyl)benzaldehyde 
• 158884-40-3 1-Methyl-2-(2,2,2-trifluoroethyl)benzene 

Relevant articles and documents

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling of Secondary α-(Trifluoromethyl)benzyl Tosylates

A palladium-catalyzed C(sp3)?C(sp2) Suzuki–Miyaura cross-coupling of aryl boronic acids and α-(trifluoromethyl)benzyl tosylates is reported. A readily available, air-stable palladium catalyst was employed to access a wide range of functionalized 1,1-diaryl-2,2,2-trifluoroethanes. Enantioenriched α-(trifluoromethyl)benzyl tosylates were found to undergo cross-coupling to give the corresponding enantioenriched cross-coupled products with an overall inversion in configuration. The crucial role of the CF3 group in promoting this transformation is demonstrated by comparison with non-fluorinated derivatives.