341-39-9

Usage

InChI:InChI=1/C9H7F3O/c1-6-4-2-3-5-7(6)8(13)9(10,11)12/h2-5H,1H3

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 95-46-5 2-methylphenyl bromide 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 
• 353-85-5 trifluoroacetonitrile 
• 354-32-5 trifluoracetyl chloride 
• 438-24-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 529-20-4 2-methylphenyl aldehyde 
• 108-88-3 toluene 
• 615-37-2 ortho-methylphenyl iodide 
• 201230-82-2 carbon monoxide 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 438-24-4 2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 80663-47-4 α-(trifluoromethyl)-2-methylstilbene 
• 131832-01-4 (R)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 438-24-4 (S)-2,2,2-trifluoro-1-(2'-methylphenyl)ethanol 
• 140854-06-4 2,2,2-trifluoro-1-(2-methylphenyl)-ethanone oxime 
• 1256347-04-2 [3-methyl-4-(trifluoromethylsulfanyl)phenyl]-(o-tolyl)-S-trifluoromethylsulfonium trifluoromethanesulfonate 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.

Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation

A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from α-CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes. A diverse array of fluoroalkyl-substituted vinylcyclopropanes are prepared in a simple, high-yielding, two-step, one-pot protocol by means of cationic ring-closure.

Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines

In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction

Selective CH Functionalization of Methane, Ethane, and Propane by a Perfluoroarene Iodine(III) Complex

Direct partial oxidation of methane, ethane, and propane to their respective trifluoroacetate esters is achieved by a homogeneous hypervalent iodine(III) complex in non-superacidic (trifluoroacetic acid) solvent. The reaction is highly selective for ester formation (>99 %). In the case of ethane, greater than 0.5 M EtTFA can be achieved. Preliminary kinetic analysis and density functional calculations support a nonradical electrophilic CH activation and iodine alkyl functionalization mechanism. Gas up: Direct partial oxidation of methane, ethane, and propane to their respective trifluoroacetate (TFA) esters is achieved by a homogeneous hypervalent iodine(III) complex in non-superacidic solvent (HTFA). The reaction is highly selective, and for ethane, greater than 0.5 M Et=TFA can be achieved. Preliminary kinetic analysis and density functional calculations support a nonradical electrophilic CH activation and iodine alkyl functionalization mechanism.

Oxime derivatives and the use thereof as latent acids

Compounds of formula I, II and III, wherein wherein R1is for example hydrogen, C1-C12alkyl, C3-C30cycloalkyl, C2-C12alkenyl, C4-C8cycloalkenyl, phenyl, whic

AN EFFICIENT SYNTHESIS OF 3-HYDROXY-3-TRIFLUOROMETHYL PHTHALIDE

An efficient synthesis of 5 is described.Conversion of bromotoluene 1 to trifluoromethylacetophenone 2 followed by a benzylic oxidation-cyclization protocol afforded the target phthalide 5.