1588973-20-9

Upstream product

• 132901-37-2 4-chloro-2-iodobenzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 

Downstream Products

• 1588973-22-1 C₂₁H₁₉ClO₃ 
• 1588971-99-6 6'-chloro-3,4,4'-triiodo-3'-(4-methoxyphenyl)-5,5-dimethyl-5H-spiro[furan-2,1'-isochromene] 
• 1588972-70-6 1-(4-chloro-2-((4-methoxyphenyl)ethynyl)phenyl)-4-hydroxy-4-methylpent-2-yn-1-one 

Relevant academic research and scientific papers

Silver-Catalyzed Sequential Cascade Reaction of Isocyanides with 1-(2-Ethynyl-phenyl)-prop-2-yn-1-ol: Access to Benzo[b]fluorenes and Benzofuran-Pyrroles

A silver-catalyzed cycloaromatization of 1-(2-ethynyl-phenyl)-prop-2-yn-1-ol with isocyanides efficiently provides benzo[b]fluorene and benzofuran-pyrrole derivatives through a modular cascade reaction that includes a nucleophilic attack on the diyne substrate. A C?C cross-coupling/oxygen transportation/Diels-Alder/hydrogen shift/isomerization cascade mechanistic pathway is proposed. (Figure presented.).

Facile synthesis of halogenated spiroketals via a tandem iodocyclization

A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in a short time and avoid the use of expensive and toxic metal catalysts. Moreover, the resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds.