132901-37-2

Upstream product

• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 244104-55-0 (4-chloro-2-iodophenyl)methanol 
• 56446-21-0 4,4-dimethyl-2-(4-chloro-2-iodophenyl)-2-oxazoline 

Downstream Products

• 1192931-79-5 1-(4-chloro-2-iodophenyl)ethanol 
• 1192931-02-4 N-(4-chloro-2-iodobenzylidene)tert-butylamine 
• 1588973-20-9 C₁₆H₁₁ClO₂ 
• 1588972-70-6 1-(4-chloro-2-((4-methoxyphenyl)ethynyl)phenyl)-4-hydroxy-4-methylpent-2-yn-1-one 
• 1588973-22-1 C₂₁H₁₉ClO₃ 
• 1588971-99-6 6'-chloro-3,4,4'-triiodo-3'-(4-methoxyphenyl)-5,5-dimethyl-5H-spiro[furan-2,1'-isochromene] 
• 1421853-73-7 methyl 3-(4-chloro-2-iodophenyl)-3-hydroxy-2-methylenepropanoate 
• 1192732-28-7 C₂₀H₁₈ClNO₃S 
• 1382240-42-7 N-allyl-N-(3-(5-chloro-2-(hydroxy(phenyl)methyl)phenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide 
• 1261035-68-0 1-(4-chloro-2-iodophenyl)hept-2-yn-1-one 

Relevant academic research and scientific papers

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N-Glycosyl Quinolin-2-ones

The synthesis of N-glycosylated quinolin-2-ones via an intramolecular N-arylation of glycosylamides is reported. The coupling involves the use of only Pd(OAc)2 as the catalyst and nBu4NOAc as the base in 1,4-dioxane. This versatile approach allows the synthesis of various N-glycosylated quinolin-2-ones with exclusive α or β selectivity.

Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine-Palladium Catalysis

Densely functionalized alkylidene indanes and indanones can be prepared efficiently in one pot, in high yields with good stereoselectivities (in some cases exclusively the Z-isomer), through a route involving phosphine-catalyzed Michael addition followed