1589071-03-3

Upstream product

• 1370641-47-6 (E)-4-(3'-methoxyphenoxy)-2-methyl-2-butenoyl chloride 
• 1563035-94-8 C₁₂H₁₄O₄ 
• 150-19-6 O-methylresorcine 
• 1562809-94-2 C₁₃H₁₆O₄ 
• 99968-60-2 4-bromo-2-methyl-but-2-enoic acid methyl ester 
• 67-56-1 methanol 
• 1589071-11-3 (S)-(2Z,4E)-2-benzylidene-6-(3″-methoxyphenoxy)-4-methyl-1-(2′-oxo-4′-phenyloxazolidin-3′-yl)-hex-4-ene-1,3-dione 

Relevant academic research and scientific papers

Convergent access to polycyclic cyclopentanoids from α,β- unsaturated acid chlorides and alkynes through a reductive coupling, nazarov cyclization sequence

Reductive coupling of α,β-unsaturated acid chlorides A with alkynoyls B provides convergent access to Nazarov cyclization precursors, α-carboxy divinyl ketones C. Cyclization of C gives an intermediate oxyallyl cation intermediate D, which can be trapped with tethered arenes (Ar). The resultant products can be further cyclized through nucleophilic displacement of suitable leaving groups X by tethered OH groups to give lactones (in a subsequent step). Where X is a suitable chiral auxiliary (e.g., oxazolidinone) this strategy affords access to homochiral cyclopentanoids.