1589071-19-1

Basic information

• Product Name: 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
• Synonyms: 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
• CAS NO: 1589071-19-1
• Molecular Weight: 376.412
• Mol File: 1589071-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile(1589071-19-1)
• EPA Substance Registry System: 2-(1-methyl-1H-indole-3-carbonyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile(1589071-19-1)

Safety Data

• Hazardous Substances Data: 1589071-19-1(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 343778-74-5 3-(1-methyl-1H-indol-3-yl)-3-oxopropanenitrile 
• 603-76-9 1-methylindole 
• 120-72-9 indole 

Relevant articles and documents

Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents

A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.