1589079-53-7

Upstream product

• 140411-20-7 4-iodo-2,6-diisopropylaniline 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 934008-46-5 N,N'-bis(4-iodo-2,6-diisopropylphenyl)1,4-diazabutadiene 
• 1394159-51-3 4-(methoxy)-2,6-diisopropylaniline 
• 1619907-28-6 N,N'-bis(4-methoxy-2,6-diisopropylphenylamino)ethane-1,2-diamine 
• 122-51-0 orthoformic acid triethyl ester 
• 1619907-20-8 N,N'-bis(4-methoxy-2,6-diisopropylphenyl)-1,4-diazabutadiene 

Relevant academic research and scientific papers

A new synthetic route to p -methoxy-2,6-disubstituted anilines and their conversion into n-heterocyclic carbene precursors

The development of new N-heterocyclic carbenes (NHC) is a key feature in this now mainstream research area to access novel chemical properties and reactivity that are essential for the discovery of original applications. Up to now, only a few reliable methods have proven suitable for the preparation of methoxylated anilines to ultimately access methoxylated NHC. We are pleased to report here a straightforward and scalable approach to address this matter. Georg Thieme Verlag Stuttgart. New York.

SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR

A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophtha!ic acid diester with sufficient Grignard reagent R2CH2MgX to form the corresponding diol product, dehydrating the diol product to the corresponding dialkene; and hydrogenating the diol product to form the corresponding aniline. The 2,6 disubstituted anilines can be used to produce N-Heterocyciic Carbenes (NHCs). The NHCs can find application in various fields such as organic synthesis, catalysis and macromolecular chemistry. Palladium catalysts containing the NHCs are also described.