158919-81-4Relevant academic research and scientific papers
Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones
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, (2008/06/13)
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatment or prophylaxis of a number of serious diseases including i) conditions relating to harmful effects of inflammatory cytokines, ii) conditions involving infection by Helicobacter species, iii) conditions involving infection by viruses, iv) neoplastic disorders, and v) conditions caused by microorganisms or parasites. The invention also relates to novel chalcones and dihydrochalcones (especially alkoxy substituted variants) having advantageous substitution patterns with respect to their effect as drug substances, and to methods of preparing them, as well as to pharmaceutical compositions comprising the novel chalcones. Moreover, the present invention relates to a method for the isolation of Leishmania fumarate reductase, QSAR methodologies for selecting potent compounds for the above-mentioned purposes.
Electron Donor-Acceptor Compounds, 50. Oligooxaparacyclophane Quinhydrones - Cation-Induced Charge-Transfer Absorptions and Structures of the Metal Complexes
Bauer, Helmut,Matz, Volker,Lang, Martina,Krieger, Claus,Staab, Heinz A.
, p. 1993 - 2008 (2007/10/02)
The intramolecular oligooxaparacyclophane quinhydrones 2-5 (with n = 3 to 6) were synthesized and their interactions with alkali and alkaline earth metal and mercury(II) ions were studied by electron absorption and NMR spectroscopy.Remarkable enhanc
