1589523-10-3Relevant academic research and scientific papers
Chiral phosphoric acid catalyzed highly enantioselective friedel-crafts alkylation reaction of c3-substituted indoles to ?2,?3-Unsaturated ?±-ketimino esters
Bi, Bo,Lou, Qin-Xin,Ding, Yu-Yang,Chen, Sheng-Wei,Zhang, Sha-Sha,Hu, Wen-Hui,Zhao, Jun-Ling
, p. 540 - 543 (2015)
A highly enantioselective C2 Friedel-Crafts alkylation reaction of 3-substituted indoles to ?2,?3-unsaturated ?±-ketimino esters has been developed. This reaction was efficiently catalyzed by a chiral phosphoric acid catalyst. The corresponding C2-substituted indole derivatives, bearing an ?±-ketimino ester motif, were obtained in moderate to high yields (up to 93%) and with high enantioselectivities (up to >99% ee).
Palladium catalyzed N-H bond insertion and intramolecular cyclization cascade: The divergent synthesis of heterocyclics
Ding, Dong,Liu, Gang,Xu, Guangyang,Li, Jian,Wang, Guoping,Sun, Jiangtao
supporting information, p. 2533 - 2537 (2014/04/17)
The palladium catalyzed carbenoid based N-H insertion and electronic effect controlled 5-exo-trig or 6-endo-trig mode Heck cyclization in one-pot has been realized for ortho-iodoanilines, in which PdCl2 was used as the single palladium resource
