158959-73-0

Upstream product

• 75415-78-0 1,2-dibromocyclopentene 
• 158959-64-9 1-(2-bromocyclopenten-1-yl)-4-(methylthio)benzene 
• 149104-88-1 4-methanesulphonylphenylboronic acid 

Downstream Products

• 158959-34-3 1-[2-(4-chlorophenyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene 
• 159429-69-3 1-(2-(4-methoxyphenyl)cyclopenten-1-yl)4-(methylsulfonyl)benzene 
• 848125-39-3 tributyl-[2-(4-methanesulfonylphenyl)cyclopent-1-enyl]stannane 
• 186804-93-3 4-[2-(2-methylpyridin-5-yl)cyclopenten-1-yl]benzenesulfonamide 
• 158959-37-6 1-[2-(4-trifluoromethylphenyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene 

Relevant academic research and scientific papers

Synthesis of18F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18F]fluoroiodobenzene as radiotracers for positron emission tomography (PET)

The Stille reaction with 4-[18F]fluoroiodobenzene as a novel approach for the synthesis of radiotracers for monitoring COX-2 expression by means of PET has been developed. Optimized reaction conditions were elaborated by screening of various ca

Substituted cyclopentenes for the treatment of inflammation

A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: STR1 wherein each of R1 and R2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkoxycarbonyl and carboxyl; wherein R5 is selected from alkylsulfonyl, haloalkylsulfonyl and sulfamyl; and wherein B is phenyl or pyridyl, wherein B is optionally substituted at a substitutable position with alkyl, halo, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl and alkoxyalkyl; or a pharmaceutically-acceptable salt thereof.

1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents

A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors. The methyl sulfone analogs 7 showed excellent COX-2 activity, with IC50s ranging from

1,2 diarylcyclopentenyl compounds for the treatment of inflammation

A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: STR1 wherein A is selected from STR2 each of R1 and R