169902-77-6Relevant academic research and scientific papers
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents
Li,Anderson,Burton,Cogburn,Collins,Garland,Gregory,Huang,Isakson,Koboldt,Logusch,Norton,Perkins,Reinhard,Seibert,Veenhuizen,Zhang,Reitz
, p. 4570 - 4578 (2007/10/02)
A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors. The methyl sulfone analogs 7 showed excellent COX-2 activity, with IC50s ranging from
