15896-61-4Relevant academic research and scientific papers
Interaction of polycationic Ni(II)-salophen complexes with G-quadruplex DNA
Lecarme, Laureline,Prado, Enora,De Rache, Aurore,Nicolau-Travers, Marie-Laure,Bonnet, Romaric,Heyden, Angeline Van Der,Philouze, Christian,Gomez, Dennis,Mergny, Jean-Louis,Jamet, Hlne,Defrancq, Eric,Jarjayes, Olivier,Thomas, Fabrice
, p. 12519 - 12531 (2015/01/16)
A series of nine Ni(II) salophen complexes involving one, two, or three alkyl-imidazolium side-chains was prepared. The lengths of the side-chains were varied from one to three carbons. The crystal structure of one complex revealed a square planar geometr
2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: Optimization of the tryptamine side chain
Young, Jonathan R.,Huang, Song X.,Walsh, Thomas F.,Wyvratt Jr., Matthew J.,Yang, Yi Tien,Yudkovitz, Joel B.,Cui, Jisong,Mount, George R.,Ren, Rena Ning,Wu, Tsuei-Ju,Shen, Xiaolan,Lyons, Kathryn A.,Mao, An-Hua,Carlin, Josephine R.,Karanam, Bindhu V.,Vincent, Stella H.,Cheng, Kang,Goulet, Mark T.
, p. 827 - 832 (2007/10/03)
A series of 2-arylindoles containing novel heteroaromatic substituents on the tryptamine tether, based on compound 1, was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. Successful modifications of 1 included chain length variation (reduction) and replacement of the pyridine with heteroaromatic groups. These alterations culminated in the discovery of compound 27kk which had excellent in vitro potency and oral efficacy in rodents.
