158984-88-4Relevant academic research and scientific papers
Synthesis of 3-[[4-(4-[18F] fluorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
Eskola, Olli,Bergman, Joergen,Lehikoinen, Pertti,Haaparanta, Merja,Groenroos, Tove,Forsback, Sarita,Solin, Olof
, p. 687 - 696 (2002)
3-[[4-(4-[18F]fluorophenyl)piperazin-1-yl]methyl] -1H-pyrrolo[2,3-b]pyridine, a candidate to image dopamine D4 receptors, was synthesised via electrophilic fluorination of a trimethylstannyl precursor with high specific radioactivity
Pyrrolo-pyridine derivatives
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, (2008/06/13)
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D 4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.
