159029-00-2

Upstream product

• 159028-71-4 5-benzyloxy-1-<2-(3-tert-butyldimethylsilyloxy)propyloxy>-ethoxypentane 
• 159028-69-0 2-(2-((5-(benzyloxy)pentyl)oxy)ethoxy)tetrahydro-2H-pyran 
• 159028-72-5 3-<2-(5-benzyloxy)-pentyloxy>-ethoxy-1-propanol 
• 159028-73-6 5-benzyloxy-1-<2-(3-bromo)-propyloxy>-ethoxypentane 
• 159028-95-2 12-(tert-butyldimethylsilyloxy)-2,4-dodecanedione 
• 159028-70-3 2-[[5-(benzyloxy)pentyl]oxy]ethan-1-ol 
• 100-39-0 benzyl bromide 
• 71268-70-7 7-((tert-butyldimethylsilyl)oxy)-1-bromoheptane 
• 4541-15-5 5-(benzyloxy)-1-pentanol 
• 629-30-1 1,7-heptandiol 
• 111-29-5 1 ,5-pentanediol 
• 10160-24-4 7-bromoheptyl alcohol 
• 159028-99-6 1-<2-(5-benzyloxy)pentyloxy>-ethoxy-15-(tert-butyldimethylsilyloxy)-5,7-pentadecanedione 

Relevant academic research and scientific papers

Design and synthesis of analogues of ionomycin

Based on the analysis of the crystal structure of the Ca2+ salt of ionomycin and the chemical and physical data on ionomycin, a number of ionomycin analogues have been synthesized to study the structural features affecting the Ca2+ binding and transport. Compounds 2, 3, and 4 were synthesized to study the effect of additional intramolecular oxygen coordination sites on Ca2+ transport. Compounds 5a-5d were prepared to study the effect of lipid solubility on Ca2+ binding and transport. Compounds 6a-6c were prepared to study the effect of the distance between the β-diketone and the carboxyl group on Ca2+ transport. A general synthetic route to these compounds has been developed. The key reactions in this route are the consecutive regioselective alkylations of the dianion of 2,4-pentanedione with the appropriate bromides.