1590366-81-6Relevant academic research and scientific papers
Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation
Chen, Rener,Gao, Yejun,Ma, Yongmin
, p. 3875 - 3882 (2019/10/11)
A simple and efficient method has been established for the synthesis of asymmetrical 2,6-diarylpyridines by cyclization of α,β,γ,δ-unsaturated ketones with ammonium formate under air atmosphere. The reaction is metal-free and operationally convenient from readily available starting materials. Thirty-three examples have been presented, most of which show good yields.
Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: One-pot synthesis of 2-arylpyridines
Shen, Yan,Chen, Jiuxi,Liu, Miaochang,Ding, Jinchang,Gao, Wenxia,Huang, Xiaobo,Wu, Huayue
supporting information, p. 4292 - 4295 (2014/04/17)
The first example of the copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters has been developed, leading to a wide range of 2-arylpyridines in a one-pot synthesis with moderate to good yields without an additional reductant. This transformation allows for rapid access to a variety of 2-arylpyridines using an inexpensive catalytic system that would be more difficult to access with traditional methods. Thus, this method represents a simple and practical procedure to access 2-arylpyridines.
