1131-33-5

Basic information

• Product Name: 2-PHENYLPYRIDINE 1-OXIDE
• Synonyms: 2-PHENYLPYRIDINE 1-OXIDE;2-PHENYLPYRIDINE N-OXIDE;1-oxidanidyl-2-phenyl-pyridin-1-ium;1-oxido-2-phenyl-pyridin-1-ium;1-oxido-2-phenylpyridin-1-ium
• CAS NO: 1131-33-5
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 1131-33-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 155-155.5 °C(Solv: benzene (71-43-2))
• Boiling Point: 400.8 °C at 760 mmHg
• Flash Point: 196.2 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 2.86E-06mmHg at 25°C
• Refractive Index: 1.573
• PKA: 0.75±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYLPYRIDINE 1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLPYRIDINE 1-OXIDE(1131-33-5)
• EPA Substance Registry System: 2-PHENYLPYRIDINE 1-OXIDE(1131-33-5)

Safety Data

• Hazardous Substances Data: 1131-33-5(Hazardous Substances Data)

Usage

General Description

2-Phenylpyridine 1-oxide, also known as α-(2-pyridyl)benzyl alcohol, is a chemical compound with the molecular formula C11H9NO. It is a pale yellow to white crystalline solid that is soluble in organic solvents. 2-PHENYLPYRIDINE 1-OXIDE is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used in the production of resins and polymers. 2-Phenylpyridine 1-oxide is known to have potential toxicity and can cause irritation to the skin, eyes, and respiratory system, therefore it should be handled with caution. Overall, this compound plays a critical role in the synthesis of various industrial and commercial products.

InChI:InChI=1/C11H9NO/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H

Upstream product

• 694-59-7 pyridine N-oxide 
• 1008-89-5 2-phenylpyridine 
• 14150-95-9 2-aminopyridine N-oxide 
• 71-43-2 benzene 
• 2402-95-1 2-chloropyridine-N-oxide 
• 98-80-6 phenylboronic acid 
• 110-86-1 pyridine 
• 591-50-4 iodobenzene 
• 65-85-0 benzoic acid 
• 108-86-1 bromobenzene 
• 14305-17-0 2-bromopyridine-N-oxide 
• 824-40-8 2-pyridinecarboxylic acid N-oxide 
• 15009-91-3 2-nitropyridine 
• 504-29-0 2-aminopyridine 

Downstream Products

• 3558-69-8 2,6-diphenylpyridine 
• 1008-89-5 2-phenylpyridine 
• 13382-54-2 2-chloro-6-phenyl-pyridine 
• 57311-18-9 4-chloro-2-phenyl-pyridine 
• 84793-92-0 (3aS,7aS)-5-Phenyl-3-m-tolyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 84794-05-8 (4-Chloro-phenyl)-(6-phenyl-pyridin-2-yl)-amine 
• 84793-95-3 (3aS,7aS)-3-(4-Chloro-phenyl)-5-phenyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 84794-03-6 N,6-diphenylpyridin-2-amine 
• 84793-91-9 (3aS,7aS)-3,5-Diphenyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 84793-93-1 (3aS,7aS)-5-Phenyl-3-p-tolyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 84794-04-7 N-(3-chlorophenyl)-6-phenyl-2-pyridinamine 
• 84793-94-2 (3aS,7aS)-3-(3-Chloro-phenyl)-5-phenyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 110-86-1 pyridine 
• 142-08-5 2-Pyridone 

Relevant articles and documents

2-Position-Selective Trifluoromethylthiolation of Six-Membered Heteroaromatic Compounds

The regioselective C-H trifluoromethylthiolation of six-membered heteroaromatic compounds via nucleophilic attack of a CF3S source on the electrophilically activated six-membered heteroaromatic ring was developed. The reaction proceeds in good yield with good functional group tolerance, even on a gram-scale. The key to the successful regioselective transformation is the presence of an additive (2,4-dinitrobenzenesulfonyl chloride). The regioselective trifluoromethylthiolation of quinidine derivative is also demonstrated. Trifluoromethylthiolation, followed by S-oxidation, affords the corresponding sulfones.

Arylation of pyridine N-oxides via a ligand-free Suzuki reaction in water

We report a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in water. This ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gi

2-Position-selective C[sbnd]H fluoromethylation of six-membered heteroaryl N-oxides with (fluoromethyl)triphenylphosphonium iodide

A mild and efficient method for the regioselective C[sbnd]H fluoromethylation of heteroaryl N-oxides with (fluoromethyl)triphenylphosphonium iodide is presented. With LiOt-Bu as the base and DMSO as the solvent, this reaction delivers a series of C2-fluor

A Photosensitizer-Free Radical Cascade for Synthesizing CF3-Containing Polycyclic Quinazolinones with Visible Light

Herein, we report an efficient photoinduced radical tandem trifluoromethylation/cyclization reaction of N-cyanamide alkenes for the synthesis of functionalized quinazolinones. Importantly, the reaction is carried out under mild conditions without any addi

Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process is initiated by the selective addition of a CF3 radical to the alkene to provide a nucleophilic alkyl radical intermediate, which enables an intramolecular endo addition exclusively to the ortho-position of the pyridinium salt. Both secondary and tertiary alkyl radicals are well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive molecules.