1590380-41-8Relevant academic research and scientific papers
FeCl3-mediated three-component cascade reaction: An effective approach to the construction of highly functionalized pyrrolo[1,2-c] quinazolinones
Zheng, Hu-Fei,Yu, Zhi-Hua,Yuan, Wei,Tang, Zi-Long,Clough, John,Gu, Yu-Cheng,Shi, De-Qing
, p. 1711 - 1719 (2014)
An unexpected FeCl3-mediated three-component cascade reaction has been used to construct structurally diverse pyrrolo[1,2-c]quinazolinone derivatives with potential biological activities. This method has advantages of mild conditions, simple work-up, as well as wide substrate scope, which makes it a powerful approach to the synthesis of diverse pyrrolo[1,2-c]quinazolinones. This cascade reaction involves 1,3-dipolar cycloaddition between azomethine ylides and allenoates, followed by intramolecular nucleophilic addition in the presence of FeCl3. The obtained products could be easily transformed into derivatives with the pyrrolo[2,3-c]quinazoline alkaloid skeleton. An iron trigger: An FeCl3-triggered three-component domino strategy enables access to highly functionalized pyrrolo[1,2-c]quinazolinones in a single step (see scheme, MS=molecular sieves). The obtained products can be used as building blocks in the synthesis of diverse, potentially biologically active nitrogen-containing heterocycles. This method features mild conditions, a simple work-up, as well as a wide substrate scope. Copyright
