1590405-75-6Relevant academic research and scientific papers
Synthesis of poly-substituted pyrazolo[1,5-a]quinolines through one-pot two component cascade reaction
Kato, Jun-Ya,Ijuin, Ryosuke,Aoyama, Hiroshi,Yokomatsu, Tsutomu
, p. 2766 - 2775 (2014)
A diversity-oriented method for the synthesis of novel poly-substituted pyrazolo[1,5-a]quinolines has been developed on the basis of an S NAr/Knoevenagel cyclization cascade reaction or an S NAr/Dieckmann-Thorpe cyclization cascade reaction. The methods provide a variety of poly-substituted pyrazolo[1,5-a]quinolines bearing an amino, alkyl or aryl substituent at the 5-position. In addition, a diversity-oriented method for the synthesis of 2-substituted pyrazolo[1,5-a]quinolines from a readily available 2-[[(trifluoromethyl) sulfonyl]oxy]pyrazolo[1,5-a]quinoline has also been disclosed.
