1590431-36-9Relevant academic research and scientific papers
Stereoselective Suzuki coupling reaction of an α-bromo-α-fluoro-β-lactam
Tarui, Atsushi,Miyata, Erina,Tanaka, Ayumi,Sato, Kazuyuki,Omote, Masaaki,Ando, Akira
, p. 55 - 58 (2015/02/18)
A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromo-α-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective manner. The synthetic utility of α-bromo-α-fluoro-β-lactam has been demonstrated by the arylation of α-bromo-α-fluoro-β-lactam.
Stereoselective Suzuki coupling reaction of an α-bromo-α-fluoro-β-lactam
Tarui, Atsushi,Miyata, Erina,Tanaka, Ayumi,Sato, Kazuyuki,Omote, Masaaki,Ando, Akira
supporting information, (2015/01/16)
A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromo-α-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective manner. The synthetic utility of α-bromo-α-fluoro-β-lactam has been demonstrated by the arylation of α-bromo-α-fluoro-β-lactam.
Ligand-promoted asymmetric imino-reformatsky reaction of ethyl dibromofluoroacetate
Tarui, Atsushi,Nishimura, Haruka,Ikebata, Takeshi,Tahira, Asuka,Sato, Kazuyuki,Omote, Masaaki,Minami, Hideki,Miwa, Yoshihisa,Ando, Akira
, p. 2080 - 2083 (2014/05/06)
An enantioselective Reformatsky reaction has been developed for the reaction of ethyl dibromofluoroacetate (1) with an imine. This method represents the first ligand-promoted imino-Reformatsky approach to use a halofluoroacetate. The use of an amino alcohol ligand allowed for the preparation of enantioenriched α-bromo-α-fluoro-β-lactams in good yields with enantioselectivities up to 96% ee. This process also provided access to β-lactam rings bearing two stereogenic centers.
