159045-50-8

Basic information

• Product Name: Imidazo[1,2-b]pyridazine-6-carboxamide (9CI)
• Synonyms: Imidazo[1,2-b]pyridazine-6-carboxamide (9CI)
• CAS NO: 159045-50-8
• Molecular Formula: C7H6N4O
• Molecular Weight: 162.14874
• Product Categories: AMIDE
• Mol File: 159045-50-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• PKA: 12.02±0.50(Predicted)
• CAS DataBase Reference: Imidazo[1,2-b]pyridazine-6-carboxamide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-b]pyridazine-6-carboxamide (9CI)(159045-50-8)
• EPA Substance Registry System: Imidazo[1,2-b]pyridazine-6-carboxamide (9CI)(159045-50-8)

Safety Data

• Hazardous Substances Data: 159045-50-8(Hazardous Substances Data)

Upstream product

• 98021-37-5 3-aminopyridazine-6-carboxamide 
• 17157-48-1 bromoacetaldehyde 

Downstream Products

• 185911-03-9 p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates 
• 185910-99-0 imidazo[1,2-b]pyridazine-6-carbaldehyde 

Relevant articles and documents

Studies on Anti-MRSA parenteral cephalosporins I. Synthesis and antibacterial activity of 7

In order to improve the antibacterial activity of cefozopran (CZOP) against methicillin-resistant Staphylococcus aureus (MRSA), we initiated chemical modification to introduce a 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyimino acetyl group at the C-7 position and a 3- or 6-substituted imidazo[1,2-b]pyridazinium or 5-substituted imidazo[1,2-a]pyridinium group at the C-3' position. Although this approach successfully enhanced the anti-MRSA activity of CZOP two to eight times, a slight decrease in the activity against Gram-negative bacteria including Pseudomonas aeruginosa was involved. Among the novel derivatives, 3-(6-aminoimidazo [1,2-b]pyridazinium-1-yl) methyl-7β-[2-(5-amino -1,2,4-thiadiazol-3-yl) -2(Z)-hydroxyiminoacetamidol]-3-cephem-4-carboxylate (44a) showed an excellent balance of activity against MRSA and Gram-negative bacteria.