Imidazo[1,2-b]pyridazine-6-carboxamide

Base Information

Chemical Name:Imidazo[1,2-b]pyridazine-6-carboxamide
CAS No.:159045-50-8
Molecular Formula:C₇H₆N₄O
Molecular Weight:162.151
Hs Code.:
DSSTox Substance ID:DTXSID80445293
Wikidata:Q82263659
Mol file:159045-50-8.mol

Synonyms:Imidazo[1,2-b]pyridazine-6-carboxamide;159045-50-8;Imidazo[1,2-b]pyridazine-6-carboxamide (9CI);SCHEMBL17303159;DTXSID80445293

Suppliers and Price of Imidazo[1,2-b]pyridazine-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
Imidazo[1,2-b]pyridazine-6-carboxamide 97.00%
25G
$ 9900.00

AccelPharmtech
Imidazo[1,2-b]pyridazine-6-carboxamide 97.00%
5G
$ 5270.00

AccelPharmtech
Imidazo[1,2-b]pyridazine-6-carboxamide 97.00%
1G
$ 3060.00

Total 1 raw suppliers

Chemical Property of Imidazo[1,2-b]pyridazine-6-carboxamide

Chemical Property:

PKA:12.02±0.50(Predicted)
PSA：73.28000
Density:1.58±0.1 g/cm3(Predicted)
LogP:0.52850
XLogP3:-0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:162.05416083
Heavy Atom Count:12
Complexity:196

Purity/Quality:: Imidazo[1,2-b]pyridazine-6-carboxamide 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC=CN2N=C1C(=O)N

Technology Process of Imidazo[1,2-b]pyridazine-6-carboxamide

There total 1 articles about Imidazo[1,2-b]pyridazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 98021-37-5
3-aminopyridazine-6-carboxamide

: 17157-48-1
bromoacetaldehyde

: 159045-50-8
6-carbamoylimidazo[1,2-b]pyridazine

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 80 ℃; for 4h;
DOI:10.7164/antibiotics.53.1053

Reference yield:

: 159045-50-8
6-carbamoylimidazo[1,2-b]pyridazine

: 185911-03-9
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / POCl₃ / 4.5 h / 115 °C

2.1: 48 percent / Raney-Ni / formic acid; H₂O / 1 h / 100 °C

3.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

3.2: 57 percent / CHCl₃ / 5.5 h / 20 °C

With sodium hydroxide; sodium chloride; trichlorophosphate; nickel; In formic acid; chloroform; water;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 159045-50-8
6-carbamoylimidazo[1,2-b]pyridazine

: 6-{2-[7-tert-butoxycarbonylamino-2-(4-methoxy-benzyloxycarbonyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-yl]-vinyl}-1-methyl-1H-imidazo[1,2-b]pyridazin-4-ylium; iodide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / POCl₃ / 4.5 h / 115 °C

2.1: 48 percent / Raney-Ni / formic acid; H₂O / 1 h / 100 °C

3.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

3.2: 57 percent / CHCl₃ / 5.5 h / 20 °C

4.1: dimethylformamide / 21 h / 20 °C

With sodium hydroxide; sodium chloride; trichlorophosphate; nickel; In formic acid; chloroform; water; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.257