1590459-82-7

Upstream product

• 65766-32-7 6-chloro-N-methylpyrimidin-4-amine 
• 1590459-81-6 6-chloro-5-iodo-N-methylpyrimidin-4-amine 
• 536-74-3 phenylacetylene 

Downstream Products

• 1590459-85-0 4-chloro-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-02-8 4-chloro-5-iodo-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-01-7 5-bromo-4-chloro-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-03-9 4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine 
• 1590460-11-9 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-[4-(trifluoromethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-10-8 4,5-bis(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-09-5 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine 
• 1590460-08-4 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(2-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine 
• 1590460-07-3 7-methyl-6-phenyl-4,5-bis-(3-tolyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-06-2 7-methyl-6-phenyl-4-(3-tolyl)-5-(4-tolyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-05-1 7-methyl-6-phenyl-4-(3-tolyl)-5-[4-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1590460-04-0 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(3-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine 
• 1590459-98-5 5-iodo-7-methyl-6-phenyl-4-[4-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]-pyrimidine 
• 1590459-97-4 5-iodo-4-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Microwave-Assisted Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines

A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of a C-6 aryl group was achieved in a two-step process under Sonogashira conditions [Pd(dba)2/CuI] followed by intramolecular cyclization, and application of Suzuki-Miyaura conditions [Pd(PPh3)4; PdCl2(PPh3)2] led to C-4 and C-5 diarylation. This sequence allows a flexible synthetic approach to highly arylated pyrrolopyrimidines containing different aryl groups.

One-pot synthesis of 4-aminated pyrrolo[2,3-d]pyrimidines from alkynylpyrimidines under metal-catalyst-free conditions

A novel, general, and efficient one-pot sequential reaction toward a variety of 4-aminated-6-arylpyrrolo[2,3-d]pyrimidines from 5-alkynylpyrimidines has been developed. Microwave-assisted metal-free intramolecular cyclization and amination provided moderate to excellent yields of 4-aminated pyrrolo[2,3-d]pyrimidines in short reaction times. This method avoids the use of metal-catalyst and expensive additives and was shown to tolerate amines and anilines.

Microwave-assisted synthesis of substituted pyrrolo[2,3-d]pyrimidines

A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of a C-6 aryl group was achieved in a two-step process under Sonogashira conditions [Pd(dba)2/CuI] followed by intramolecular cyclization, and application of Suzuki-Miyaura conditions [Pd(PPh 3)4; PdCl2(PPh3)2] led to C-4 and C-5 diarylation. This sequence allows a flexible synthetic approach to highly arylated pyrrolopyrimidines containing different aryl groups. A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. Copyright