65766-32-7

Basic information

• Product Name: 6-chloro-Nmethylpyrimidin-4-amine
• Synonyms: 6-chloro-Nmethylpyrimidin-4-amine;4-Pyrimidinamine, 6-chloro-N-methyl- (9CI);4-Chloro-6-methylaminopyrimidine;EOS-60926
• CAS NO: 65766-32-7
• Molecular Formula: C₅H₆ClN₃
• Molecular Weight: 143.57424
• Product Categories: amine|alkyl chloride;PYRIMIDINE;Amines;blocks;APIs & Intermediate
• Mol File: 65766-32-7.mol
• Article Data: 27

Chemical Properties

• Melting Point: 138-142°C
• Boiling Point: 279.7 °C at 760 mmHg
• Flash Point: 122.9 °C
• Appearance: /
• Density: 1.338 g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.50±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-Nmethylpyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)
• EPA Substance Registry System: 6-chloro-Nmethylpyrimidin-4-amine(65766-32-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 65766-32-7(Hazardous Substances Data)

Usage

General Description

6-chloro-Nmethylpyrimidin-4-amine is a chemical compound with the molecular formula C5H6ClN3. It is a pyrimidine derivative with a chloro substituent at the 6-position and a methyl group at the N-position. 6-chloro-Nmethylpyrimidin-4-amine is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It may also have potential applications in medicinal chemistry and drug development. The chemical properties and reactivity of 6-chloro-Nmethylpyrimidin-4-amine make it important for the development of new drugs and biologically active compounds.

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 74-89-5 methylamine 
• 32998-03-1 (2,6-dichloro-pyrimidin-4-yl)-methyl-amine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 872509-58-5 N-methyl-N'-[4-(4-methyl-piperazin-1-yl)phenyl]pyrimidine-4,6-diamine 
• 943605-97-8 6-(2-fluoropyridin-3-yl)-N-methylpyrimidin-4-amine 
• 943189-22-8 N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine 
• 872511-35-8 of N⁴-(4-(4-ethylpiperazin-1-yl)phenyl)-N⁶-methylpyrimidine-4,6-diamine 

Relevant articles and documents

Discovery of 4,6-Disubstituted Pyrimidine Derivatives as Novel Dual VEGFR2/FGFR1 Inhibitors

Abnormalities in the FGFRs signaling pathway and VEGFR2 amplification often occur in a variety of tumors, and they synergistically promote tumor angiogenesis. Studies have shown that the up-regulation of FGF-2 is closely related to the resistance of VEGFR2 inhibitors. Activation of the FGFRs signal is a signal of compensatory angiogenesis after VEGFR2 resistance. Dual VEGFR2/FGFR1 inhibitors contribute to overcoming the resistance of VEGFR2 inhibitors and inhibit tumor growth significantly. Based on this, we designed and synthesized a series of 4,6-disubstituted pyrimidine derivatives as dual VEGFR2/FGFR1 inhibitors by the molecular hybridization strategy. 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-[(4-methoxyphenyl)amino]pyrimidin-4-yl}-1-methylurea (8b) had the best inhibitory activities against VEGFR2 and FGFR1 at 10 μM (82.2 % and 101.0 %, respectively), it showed moderate antiproliferative activities against A549 and KG-1 cell lines as well. Besides, molecular docking was also carried out to study the binding mode of 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{6-[(4-methoxyphenyl)-amino]-pyrimidin-4-yl}-1-methylurea (8b) with VEGFR2 and FGFR1. These studies reveal that this series of compounds deserve further optimization.

Substituted p-chlorophenyl acetylpiperazine-containing compound as well as preparation method and application thereof

The application provides a substituted p-chlorophenyl acetylpiperazine-containing compound as well as a preparation method and application of the substituted p-chlorophenyl acetylpiperazine-containingcompound. The compound has the structure shown in the formula (I), and has better Akt1 inhibitory activity or growth inhibitory activity to MCL cell lines.

CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS

The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal cells. Particularly, the compounds of the invention have stronger inhibition effect on bladder cance