15911-11-2

Basic information

• Product Name: 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: 4-acetyl-5-methyl-3-isoxazolecarboxylicacidethylester;4-acetyl-5-methyl-3-isoxazolecarboxylicaciethylester;ETHYL 4-ACETYL-5-METHYLISOXAZOLE-3-CARBOXYLATE;5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER;4-Acetyl-5-methylisoxazole-3-carboxylic acid ethyl ester;Ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate, 4-Acetyl-3-(ethoxycarbonyl)-5-methylisoxazole
• CAS NO: 15911-11-2
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.19
• Mol File: 15911-11-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 102 °C
• Flash Point: 159.4°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 8.91E-05mmHg at 25°C
• Refractive Index: 1.483
• CAS DataBase Reference: 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER(15911-11-2)
• EPA Substance Registry System: 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER(15911-11-2)

Safety Data

• Hazard Codes: Harmful:
• HazardClass: IRRITANT
• Hazardous Substances Data: 15911-11-2(Hazardous Substances Data)

Usage

General Description

5-Ethyl-isoxazole-3,4-dicarboxylic acid diethyl ester is a chemical compound with the molecular formula C12H17NO6. It is an ester of isoxazole-3,4-dicarboxylic acid and is commonly used as a building block in organic synthesis. This chemical is also used as an intermediate in the production of pharmaceuticals, agricultural chemicals, and other specialty chemicals. It is considered to be a potentially hazardous chemical and should be handled and stored with care.

InChI:InChI=1/C9H11NO4/c1-4-13-9(12)8-7(5(2)11)6(3)14-10-8/h4H2,1-3H3

Upstream product

• 95080-93-6 ethyl chlorooximidoacetate 
• 123-54-6 acetylacetone 
• 626-35-7 nitroacetic acid ethyl ester 
• 861135-87-7 chlorohydroxyimino-acetic acid ethyl ester 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 
• 216962-12-8 3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester 
• 1118-67-8 sodium (Z)-4-oxopent-2-en-2-olate 

Downstream Products

• 15911-14-5 5-methyl-4-[1-(phenyl-hydrazono)-ethyl]-isoxazole-3-carboxylic acid ethyl ester 
• 15911-15-6 3,4-dimethyl-6-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one 
• 1340474-40-9 ethyl 5-(4-trifluoromethylbenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate 
• 1340474-39-6 ethyl 5-benzyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate 
• 1340474-38-5 ethyl 5-(4-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate 
• 1340474-37-4 ethyl 5-(3-methoxybenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate 
• 1208102-76-4 3,4-dimethyl-6-(4-(trifluoromethyl)phenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one 
• 263755-65-3 3,4-dimethyl-6-(4-methoxyphenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one 
• 263890-21-7 3,4-dimethyl-6-p-tolylisoxazolo[3,4-d]pyridazin-7(6H)-one 
• 263890-31-9 3,4-dimethyl-6-(4-nitrophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one 
• 1208102-85-5 5-methyl-4-(1-[(4-nitro-phenyl)-hydrazono]-ethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 1208102-86-6 5-methyl-4-(1-[(2-nitro-phenyl)-hydrazono]-ethyl)-isoxazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc-rter: Initial homology model

Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.

Base- and copper-catalysed condensation of primary activated nitro compounds with enolisable compounds

Primary nitro compounds have not been employed as nitrile oxide precursors in reactions with active methylene compounds because the reagents commonly used as dehydrating agents also react with these dipolarophiles. However, the Cu II-catalysed

[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents

A number of [(3-chlorophenyl)piperazinylpropyl]pyridazinones and the corresponding isoxazolopyridazinones, showing the arylpiperazinyl substructure present in very potent antinociceptive agents reported in the literature, were synthesized and tested for t