159110-62-0Relevant academic research and scientific papers
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
Vargas M., Leonor Y.,Castelli, Maria V.,Kouznetsov, Vladimir V.,Urbina G., Juan M.,Lopez, Silvia N.,Sortino, Maximiliano,Enriz, Ricardo D.,Ribas, Juan C.,Zacchino, Susana
, p. 1531 - 1550 (2007/10/03)
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
SYNTHESIS OF 2-ALKYL(ARYL, HETARYL)-4-METHYL-1,2,3,4-TETRAHYDROQUINOLINES
Kuznetsov, V. V.,Aliev, A. E.,Prostakov, N. S.
, p. 64 - 68 (2007/10/02)
We have developed a preparative, three stage of synthesis of substituted 1,2,3,4-tetrahydroquinolines.Treatment of N-aryl-imines with allylmagnesium bromide gave N-aryl-N-alkenylamines which were cyclized to the tetrahydroquinolines.The configurations and
